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KMID : 0378019870300010091
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New Medical Journal
1987 Volume.30 No. 1 p.91 ~ p.109
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Clinical Trial of Ambroxol on Chronic Bronchitis
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Abstract
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Ambroxol, trans-4[(2-amino-3, 5-dibromobenzyl)-amino]-cyclohexanol hydrochloride, is newly developed expectorant, facilitating expectoration by increasing mucociliary action, by mucolysis and inhibition of sputum production, and by secretion of surfactant substances in the lung. We have evaluated the clinical effect of ambroxol on 25 chronic bronchitis patients..60mg of Ambroxai was administered orally 3 times a day for 8 weeks and symptom monitoring with respiratory questionnaire, pulmonary function test and LFT, BUN/Creatinine were checked regularly.
After 4 weeks treatment, symptoms were much improved, ie, cough 84%, ease of expectoration 92% viscosity of sputum 88%, volume of sputum 64%, color of sputum 72% and dyspnea 60%.But no significant further improvement was noted after initial 4 weeks. The response rate was much better in mile cases (FEV,/FVC more than 65%) than in severe cases (FEV,/FVC less than 65%). There was no significant side effect except mild gastrointestinal symptoms and one case of transient elevation of transaminase. We concluded that ambroxol is a safe and effective expectorant in chronic bronchitis patients and its effect is more pronounced in mild cases.
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